Research interests:

• Discovery and validation of DNA methylation based biomarkers of human cancers prevalent in North East India.
• Studies on heavy metal pollution in water bodies of Meghalaya.
• Role of metallotheinein and stress genes as biomarkers of pollution in aquatic ecosystems.
• Study on role of pesticides on the development of an anuran species.
• Study on the effect of air pollution on chromosomal aberrations using Drosophila as a model.
• DNA bar coding of fish species of Meghalaya.

Research/Academic experiences:

• Professor in Zoology: (May 2019 to present). Teaching M.Sc. students and Ph.D. course work students, guiding M.Sc. dissertation and Ph.D. students at Dept. of Zoology, North Eastern Hill University
• Associate Professor in Zoology: (July 2009-May2019).Teaching M.Sc.and Ph.D. course work students, guiding Ph.D. students at Dept. of Zoology, North Eastern Hill University
• Principal Investigator of three Govt. of India sponsored projects(see detail below)
• Ph.D. student(s): Awarded(4); Guiding (6)
• Framing of Syllabus: As the sole teacher of Genetics in the department framed new NEP 2020 syllabus for Genetics in the department.
• Paper setter/ examiner: In the capacity of paper -in-charge have been working as paper setter and internal examiner for Genetics. Have been setting questions for State level eligibility and entrance exams. Acting as external examiner for Ph.D. thesis submitted to various universities.
• Resource person: Delivered lectures in Refresher Course for Zoology at UGC-Academic Staff College, North Eastern Hill University for the years 2012 and 2019.
• Developing teaching proficiency: Actively participated in Post-Doctoral Teaching and Learning Certificate Program of SUNY@ Buffalo (2008).
• Oncology for scientists (course work 530 and 532): Taught Chemical Carcinogenesis as part of team-teaching to graduate students (MS and Ph.D.) of Roswell Park Cancer Institute, SUNY@ Buffalo. This year long course is a comprehensive survey from the basic biology of cancer at the molecular, cellular, and genetic levels, to the clinical manifestation of disease. It creates a unique starting point for graduate students who will enter a cancer research area in their degree programs.
• Assistant teacher of Biology: Taught Biology, specifically Zoology, Cell Biology and Genetics to students of Class XI and XII (CBSE board) at Salt Lake School in Calcutta from 1998 to 1999.
• Science teacher for Teacher’s Training Center (T.T.C.) Program of Govt. of West Bengal: Taught trainees at Educational Support Center, Calcutta from 1996-1998. Helped set up the science laboratory and taught would -be primary school teachers all science subjects including physics, chemistry and biology

Administrative experiences/responsibilities:

• Worked as Warden for Post Graduate Girl's Hostel (Umiam Hostel) accommodating 100 students at North Eastern Hill University from Oct 2009 to June 2023.
• As a member of Women’s Cell NEHU, Shillong, participated in drafting of ordinance for sexual harassment of women at work place.
• Member of School Board of Life Sciences.
• Member of DRC.
• Convener of Departmental Admission Committee for M.Sc. and Ph.D.
• Member of Academic Council.

Postdoctoral Research Experience:

• Oct.2005 – Jun.2009: Postdoctoral Associate with Dr. Hiroki Nagase and Dr. Michael Higgins @ Roswell Park Cancer Institute, Dept. of Cancer Genetics, Buffalo, NY USA
• Jan.2004 –Sept.2005: Postdoctoral Research Affiliate with Dr. Dominic J Smiraglia @ Roswell Park Cancer Institute, Dept. of Cancer Genetics, Buffalo, NY,USA
• Sept.2003- Jan.2004: Postdoctoral Fellow with Dr. Parsa Kazemi-Esfarjani @ Dept. of Physiology and Biophysics, SUNY at Buffalo, Buffalo, NY,USA
• Dec.2000- Aug.2003: Postdoctoral Fellow with Dr. Mel B. Feany @ Dept. of Pathology, Brigham & Women’s Hospital, Harvard Medical School, Boston, MA,USA

Pre-doctoral Research Experience:

• 1997-98: Research project sponsored by Dept. of Science and Technology, West   Bengal, India
• Project title: Polymorphism at the level of DNA and protein as genetic marker in response to heavy metal stress, insecticides, detergents and crude oil surfactants
• Supervisor: Dr. Ashish K. Duttagupta, Dept. of Zoology, University of Calcutta, India
• 1993-96: Graduate research project sponsored by Dept. of Atomic Energy, Govt. of India.
• Project title: Position effect variegation (PEV) as a system to expose genomic domains that are involved in the control of PEV, homeotic pathway, developmental regulations and retrotransposons insertional mutations in D. melanogaster
• Supervisor: Dr. Ashish K. Duttagupta, Dept. of Zoology, University of Calcutta, India

Honors and Fellowships Awarded:

International Conferences/Symposia/Workshops:

• International Conference on Molecular signaling: November 20-22, 2015, Dept. of Zoology, NEHU, Shillong
• SERB School in Chronobiology: June 20 to July 03, 2012 at Dept. of Zoology, NEHU Shillong
• AACR Special Conference: Cancer Epigenetics. May 28-31, 2008. Boston, MA, USA.
• 44^th Annual Drosophila Research Conference. Chicago, USA; March, 2003
  Partners Program in Alzheimer’s and Other Neurodegenerative Diseases Colloquium. Boston, USA; March, 2001.
• Third International Conference on DNA fingerprinting. CCMB, Hyderabad, India; December, 1994 Workshop on DNA technology: Application in the diagnosis of human diseases. The Vivekananda Institute of Medical Sciences and Ramkrishna Mission Seva Pratishthan, Calcutta, India; December, 1992
• The First Drosophila meeting: Presented paper titled ‘Fine structure of a suppressor that alter the haplo X spiralization’. University of Mysore, India; March, 1992

Research Projects

Research Projects completed:

Lab members: Present

Lab Members: Past

Publications

Publication and Citation Summary (Google Scholar):

Peer reviewed:

1. Anal, BV., Alom, S., & Ghosh, S. (2026). Methylated DNA in Oral Brush and Salivary Rinse as a Non-Invasive Biomarker in the Diagnosis and Prognosis of Oral Cancer: A narrative review. Journal of Clinical Diagnosis and Research. (Accepted)
2. Ghosh, S., Bagchi, I., Marthong, L., Patra, S., Shunyu, N. B., Ghosh, S., & Maitra, A. (2026). Genebody specific epigenomic reprogramming of transcriptome promotes immune evasion in oropharyngeal cancer patients in North-Eastern India. Clinical Epigenetics. https://doi.org/10.1186/s13148-026-02088-y
3. Anal, B. V., Alom, S., & Ghosh, S. (2025). Cancer Trends in Northeast India: An Overview. The NEHU Journal, 12(1–2), 44–53.
4. Lyngkhoi, E., Lartang, B., Shangpliang, P. W., & Ghosh, S. (2025). Impact of organophosphate pesticides on anurans: A mini review. Basic and Applied Herpetology, 39, 5–26. https://doi.org/10.11160/bah.309
5. Anal, B. V., Alom, S., & Ghosh, S. (2025). Methylated DNA as a Diagnostic Biomarker of Esophageal Cancer in the Indian Population and its Association with Risk Factors. Advances in Bioresearch, 16(5), 402–409. https://doi.org/10.15515/abr.0976-4585.16.5.402409
6. Lyngkhoi, E., Lartang, B., & Ghosh, S. (2025). Pesticides and human health: A double-edged sword in modern agriculture. The NEHU Journal, 21(1–2), 32–50.
7. Alom, S., & Ghosh, S. (2025). CONSORT2025: A Shiny/R application for generating CONSORT 2025-compliant flow diagram for randomized two-arm clinical trials with comprehensive data input options.
8. Alom, S., Anal, B. S. V., & Ghosh, S. (2025). Recently Emerging Liquid Biopsy-based Non-invasive Methylation Biomarkers for Gastric Cancer Diagnosis, Prognosis and Therapy Response Prediction. In Current Cancer Therapy Reviews (Vol. 21, Issue 7, pp. 982–993). Bentham Science Publishers. https://doi.org/10.2174/0115733947313656240819093316
9. Warjri, C. D., Kshetriya, D., & Ghosh, S. (2024). Seasonal variation of heavy metals in water and Cyprinus carpio L. from Umiam Lake reservoir of Meghalaya, India: Potential health risk assessment for human consumption. Environmental Science and Pollution Research, 31(27), 39782–39793. https://doi.org/10.1007/s11356-024-33778-w
10. Lamare, F. A., Khongsti, S., Marthong, L., Ghosh, S., Chenkual, S., Dkhar, H., Maitra, A., & Ghosh, S. (2022). Genome-wide DNA methylation profiling of stomach cancer in the ethnic population of Mizoram, North East India. Genomics, 114(5), 110478. https://doi.org/10.1016/j.ygeno.2022.110478
11. Kshetriya, D., Warjri, C. D., Chakrabarty, T. K., & Ghosh, S. (2021). Assessment of heavy metals in some natural water bodies in Meghalaya, India. Environmental Nanotechnology, Monitoring & Management, 16, 100512. https://doi.org/10.1016/j.enmm.2021.100512
12. Marthong, L., Ghosh, S., Palodhi, A., Imran, M., Shunyu, N. B., Maitra, A., & Ghosh, S. (2020). Whole Genome DNA Methylation and Gene Expression Profiling of Oropharyngeal Cancer Patients in North-Eastern India: Identification of Epigenetically Altered Gene Expression Reveals Potential Biomarkers. Frontiers in Genetics, 11, 986. https://doi.org/10.3389/fgene.2020.00986
13. Khongsti, S., Shunyu, B., & Ghosh, S. (2019). Promoter-associated DNA methylation & expression profiling of genes (FLT 3, EPB41L3 & SFN) in patients with oral squamous cell carcinoma in the Khasi & Jaintia population of Meghalaya, India. Indian Journal of Medical Research, 150(6), 584. https://doi.org/10.4103/ijmr.IJMR_620_18
14. Khongsti, S., Lamare, F. A., Shunyu, N. B., Ghosh, S., Maitra, A., & Ghosh, S. (2018). Whole genome DNA methylation profiling of oral cancer in ethnic population of Meghalaya, North East India reveals novel genes. In Genomics (Vol. 110, Issue 2, pp. 112–123). Academic Press Inc. https://doi.org/10.1016/j.ygeno.2017.09.002
15. Hasegawa, R., Fujiwara, K., Obinata, D., Kawashima, H., Shinojima, Y., Igarashi, J., Wang, X., Ghosh, S., Nagase, H., & Takahashi, S. (2014). Identification of Frequent Differentially Methylated Region in Sporadic Bladder Cancers. Urologia Internationalis, 94(4), 479–484. https://doi.org/10.1159/000365197
16. Fujiwara, K., Ghosh, S., Liang, P., Morien, E., Soma, M., & Nagase, H. (2015). Genome???wide screening of aberrant DNA methylation which associated with gene expression in mouse skin cancers. Molecular Carcinogenesis, 54(3), 178–188. https://doi.org/10.1002/mc.22085
17. Uekusa, S., Kawashima, H., Sugito, K., Yoshizawa, S., Shinojima, Y., Igarashi, J., Ghosh, S., Wang, X., Fujiwara, K., Ikeda, T., Koshinaga, T., Soma, M., & Nagase, H. (2014). Nr4a3, a possibile oncogenic factor for neuroblastoma associated with CpGi methylation within the third exon. International Journal of Oncology, 44(5), 1669–1677. https://doi.org/10.3892/ijo.2014.2340
18. Sugito, K., Kawashima, H., Uekusa, S., Yoshizawa, S., Hoshi, R., Furuya, T., Kaneda, H., Hosoda, T., Masuko, T., Ohashi, K., Ikeda, T., Koshinaga, T., Fujiwara, K., Igarashi, J., Ghosh, S., Held, W. A., & Nagase, H. (2013). Identification of aberrant methylation regions in neuroblastoma by screening of tissue???specific differentially methylated regions. Pediatric Blood & Cancer, 60(3), 383–389. https://doi.org/10.1002/pbc.24282
19. Nagase, H. (2011). DNA hypomethylation at the ZNF206-exon 5 CpG island associated with neuronal differentiation in mice and development of neuroblastoma in humans. International Journal of Oncology. https://doi.org/10.3892/ijo.2011.1234
20. Liang, P., Song, F., Ghosh, S., Morien, E., Qin, M., Mahmood, S., Fujiwara, K., Igarashi, J., Nagase, H., & Held, W. A. (2011). Genome-wide survey reveals dynamic widespread tissue-specific changes in DNA methylation during development. BMC Genomics, 12(1), 231. https://doi.org/10.1186/1471-2164-12-231
21. Ghosh, S., Yates, A. J., Frühwald, M. C., Miecznikowski, J. C., Plass, C., & Smiraglia, D. (2010). Tissue specific DNA methylation of CpG islands in normal human adult somatic tissues distinguishes neural from non-neural tissues. Epigenetics, 5(6), 527–538. https://doi.org/10.4161/epi.5.6.12228
22. Shinojima, Y., Terui, T., Hara, H., Kimura, M., Igarashi, J., Wang, X., Kawashima, H., Kobayashi, Y., Muroi, S., Hayakawa, S., Esumi, M., Fujiwara, K., Ghosh, S., Yamamoto, T., Held, W., & Nagase, H. (2010). Identification and analysis of an early diagnostic marker for malignant melanoma: ZAR1 intra-genic differential methylation. Journal of Dermatological Science, 59(2), 98–106. https://doi.org/10.1016/j.jdermsci.2010.04.016
23. Song, F., Mahmood, S., Ghosh, S., Liang, P., Smiraglia, D. J., Nagase, H., & Held, W. A. (2009). Tissue specific differentially methylated regions (TDMR): Changes in DNA methylation during development. Genomics, 93(2), 130–139. https://doi.org/10.1016/j.ygeno.2008.09.003
24. Igarashi, J., Muroi, S., Kawashima, H., Wang, X., Shinojima, Y., Kitamura, E., Oinuma, T., Nemoto, N., Song, F., Ghosh, S., Held, W. A., & Nagase, H. (2008). Quantitative analysis of human tissue-specific differences in methylation. Biochemical and Biophysical Research Communications, 376(4), 658–664. https://doi.org/10.1016/j.bbrc.2008.09.044
25. Nagase, H., & Ghosh, S. (2008). Epigenetics: Differential DNA methylation in mammalian somatic tissues. The FEBS Journal, 275(8), 1617–1623. https://doi.org/10.1111/j.1742-4658.2008.06330.x
26. Wang, S. S., Smiraglia, D. J., Wu, Y.-Z., Ghosh, S., Rader, J. S., Cho, K. R., Bonfiglio, T. A., Nayar, R., Plass, C., & Sherman, M. E. (2008). Identification of Novel Methylation Markers in Cervical Cancer Using Restriction Landmark Genomic Scanning. Cancer Research, 68(7), 2489–2497. https://doi.org/10.1158/0008-5472.CAN-07-3194
27. Kitamura, E., Igarashi, J., Morohashi, A., Hida, N., Oinuma, T., Nemoto, N., Sekine, N., Moriyama, M., Takayama, T., Song, F., Ghosh, S., Held, W., Yoshida-Noro, C., & Nagase, H. (2007). Tissue-specific differentially methylated regions (TDMs) in humans and aberrant DNA methylations in liver tumors. Cancer Research, 67(9_Supplement), 2874–2874.
28. Kitamura, E., Igarashi, J., Morohashi, A., Hida, N., Oinuma, T., Nemoto, N., Song, F., Ghosh, S., Held, W. A., Yoshida-Noro, C., & Nagase, H. (2007). Analysis of tissue-specific differentially methylated regions (TDMs) in humans. Genomics, 89(3), 326–337. https://doi.org/10.1016/j.ygeno.2006.11.006
29. Fayazi, Z., Ghosh, S., Marion, S., Bao, X., Shero, M., & Kazemi-Esfarjani, P. (2006). A Drosophila ortholog of the human MRJ modulates polyglutamine toxicity and aggregation. Neurobiology of Disease, 24(2), 226–244. https://doi.org/10.1016/j.nbd.2006.06.015
30. Ghosh, S., & Feany, M. B. (2004). Comparison of pathways controlling toxicity in the eye and brain in Drosophila models of human neurodegenerative diseases. Human Molecular Genetics, 13(18), 2011–2018. https://doi.org/10.1093/hmg/ddh214
31. Mukhopadhyay, S., Chakrabarti, D., Ghosh, S. and Duttagupta, A. K. (1995) Transacting suppressors that affect the haplo X-chromatin packaging of the giant (gt) mutant of Drosophila melanogaster. Proc. Zool. Soc., Calcutta Vol. 47(2): 107 –123. (ISSN Print: 0373-5893; Online: 0974-6919) (Impact factor 0.38, 2018)

Abstracts:

1. Srimoyee Ghosh , Kyoko Fujiwara , Jun Igarashi , Yui Shinojima ,Hiroyuki   Kawashima, Evan Morien  and Hiroki Nagase. Global CpG island methylation screening identifies novel genes that are epigenetically altered in mouse skin cancer model. AACR Special Conference: Cancer Epigenetics. May 28-31, 2008. Boston, MA, USA.
2. Hiroki Nagase, Srimoyee Ghosh, Kyoko Fujiwara, Williams Held, Eiko Kitamura. ‘Analysis of DNA methylation in tissue development and carcinogenesis in C57BL/6J mice’. Human Genome Organization's (HUGO) 12th Human Genome Meeting, Mon 21-Thu 24 May 2007.  Montreal, Canada.
3. Dominic J Smiraglia, Srimoyee Ghosh, Donald Trump; and James Mohler. ‘CpG island methylation screening reveals excessive aberrant methylation in recurrent human prostate cancer compared to androgen stimulated primary prostate cancer’. Innovative minds in Prostate cancer today (IMPACT) Dept. of Defense Prostate Cancer research program meeting. Sept 5-8, 2007. Atlanta, GA, USA.

International Conferences/Symposia/Workshops:

• International Conference on Molecular signaling: November 20-22, 2015, Dept. of Zoology, NEHU, Shillong
• SERB School in Chronobiology: June 20 to July 03, 2012 at Dept. of Zoology, NEHU Shillong
• AACR Special Conference: Cancer Epigenetics. May 28-31, 2008. Boston, MA, USA.
• 44^th Annual Drosophila Research Conference. Chicago, USA; March, 2003
  Partners Program in Alzheimer’s and Other Neurodegenerative Diseases Colloquium. Boston, USA; March, 2001.
• Third International Conference on DNA fingerprinting. CCMB, Hyderabad, India; December, 1994 Workshop on DNA technology: Application in the diagnosis of human diseases. The Vivekananda Institute of Medical Sciences and Ramkrishna Mission Seva Pratishthan, Calcutta, India; December, 1992
• The First Drosophila meeting: Presented paper titled ‘Fine structure of a suppressor that alter the haplo X spiralization’. University of Mysore, India; March, 1992

Expertise in research techniques:

Molecular Biology:Southern hybridization including RFLP, sub-cloning, PCR including RAPD, in situ hybridization: radioactive and non-radioactive, site-directed mutagenesis, RNA isolation and gene expression assay, gene silencing by siRNAs

Methylation Analyses: Restriction Length Genomic Scanning (RLGS), Bisulfite sequencing, Methylation Specific PCR (MSP), MethyLight assay (Q-MSP), primer designing and data analyses for methylation study using MALDI-TOF MS assay from Sequenom, MeDIP assay for CpGi and promoter array analyses, knowledge of Combined Bisulfite Restriction Analysis (COBRA)

Protein Chemistry: 2-D gel electrophoresis of proteins, in vitro protein expression and interaction, western blotting, isozyme analysis

Fly Techniques: Micro-injection of Drosophila embryo, immunohistochemistry of Drosophila brain sections,     P-mediated mutagenesis & enhancer-trap technique in Drosophila, Drosophila genetics including fine structure analysis, autoradiography of Drosophila polytene chromosomes

Tissue/Cell culture: Mammalian cell culture, Drosophila cell culture